To make serious power, you need a serious foundation to start. Build the engine first, then add boost.
Dart or Man-O-War 351 block, bore and stroke it to 408 or 427.
This means either a Callies, Kellogg, or Lunati Sledgehammer crank. H beam aluminum rods from Carillo, Lunati, or Manley. Pistons need to give approximately 8-8.5:1 compression at the maximum. Make sure they have a ring package for the intended boost, this means the rings might be moved down the skirt of the piston to avoid burning them.
Heads would have to be some serious units like the TFS R series, AFR 225, Edelbrock Vic Glidden. You'll want a shaft rocker system like one from Jesel.
I'm guessing you want it to be EFI. This would mean 160 lb injectors, a tunable computer control system like F.A.S.T. or DFI. For the intake, you could try a CHP Spyder made from a Super Victor intake.
The cam would need to be a solid roller and you'd be highly advised to get a custom grind. You could check these guys.
www.elgincams.com (Dema Elgin, LEGEND, making his own cams since 1957, for the old school touch. STILL there, and you can talk to the guys who make your cam and they will tell you what they plan to do, without worrying about whether or not their secret mojo will get "stolen").
www.integralcams.com (Big corporate race shop, very high tech, high end, pricey. NASCAR teams work with them). $1100-3000 for a REAL custom developed camshaft. Or more. No BS.
www.claysmithcams.com (Mike Jones, camshaft tech and engine guy - well-known in the North East). Though I think his new business is Ultra Pro Racing Cams. He grinds his own cams, and he can even do inverse curves (at the base of the lobes) when they will help a custom cam project. Interesting concept...
Some factors the cam designer needs to know: Bore, stroke, rod length, static compression ratio, carburetion and flow, planned rpm range, port flow, valve size, valve seat angles, heads and intake manifold. Mr. Iskendarian (of Isky fame) will also discuss your project with you and tell you what specs he will build for your custom cam project.
A 408 or 427 stroker built this way will be at least 500 engine hp. Add in some boost from a 76mm turbo and you'd hit that number but there's no way to guess what kind of manners this engine would have or if you could drive it on the street.