Yes, all you need to do is put some bolts in there to plug it up. Or you can leave it open, it doesnt matter. The only thing that flows through there is tranny fluid and you dont need a cooler for a manual. No antifreeze will leak out of it. If any does, then your radiator is junk and you need a new one.
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1993 GT Hatch: 306 with Twisted Wedge heads,TFS stage one cam,TFS upper/lower intake, 190lph fuel pump, 30lb injectors, 70mm TB/EGR plate, Granatelli MAF= now using Pro-M, Lakewood upper/lower control arms, powertrax diff, subframe connectors, Eibach springs, aluminum ds, t56 trans, Eibach swaybars, Flowtech LT's, Magnaflow CB, 17x10.5 deep dish cobras in rear, 17x9 cobras in front.
Marine Detachment, Keesler AFB, Biloxi MS
OOORAAHH!!!
I've always just bought the cheapo lifetime radiators at vatozone, for my 5.0s, and they all came with tranny coolers. They usually include metal plugs which thread into the line fittings.
I'd be inclined to plug the holes, in case you ever want to use the cooler.
I don't see why bolts would't work, as long as they are the correct size, with the correct pitch to the threads.
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1992 Deep Emerald Green Mustang GT Hatch, 5 speed, 2.73s, Mac fenderwell cold air intake, '93 Cobra MAF, Mac 70mm throttle body & spacer, Explorer intakes, Mac unequal headers & offroad pipe, Magnaflow catback, Walbro 110lph fuel pump, Jet adjustable FPR, MSD Blaster coil, Accel 8mm wires, FRPP aluminum quadrant, UPR firewall adjuster, stock cable, Granatelli upper control arms.
Waiting to go on: Granatelli lower control arms, and GT40 Iron heads!
radiator differences, auto vs. manual 
