Hello, the answer is YES and I have done 4 so far with great success. The 4R70W is a 4 spd with OD = 5 forward ratios.
You will need a special
trans mount(I make and sell them $50), shorten your driveshaft, and all the usual stuff but you will need a Baumanengineering.com transmission computer and wiring harness. the controller and wiring is usually 4-500$.
Find a local junkyard and get a 98-2001 4r70w from a v6($250 - 450) mustang. they have the small block bellhousing and will bolt to a 289 to a 351C. get the torque onverter and use your original flywheel.
I have one of these for 4 years now behind a strong 351C and I dont drive easy. the
trans shifts like a crown vic until you nail the gas and hold on. I had 3.89 gears and turned 2300 at 60 in od with 26.8"tires. Currie enterprises has a website and an rpm calculator you can use for free, your OD will be a final drive ratio of .67:1
Dont let anyone tell you otherwise - I have done it and love it,I did it for both my brothers and a buddy of mine and it is great.
You will have to do some small things but I will help you - message me. It clears everthing but you will have to redo your exhaust.
By the way a 4R70W has a lower 1st(2.84:1) gear than a c-4,FMX or C6
Joe