Yes you can and its fairly simple, less than a few hours. You'll need a special steering wheel puller tool that can be rented free from local parts stores like o'reilly, and some common tools, particularly a 15/16 socket for the retaining nut.
I'm not sure what type of wheel you're removing or the parts, but a good rule of thumb is to document each part as it's removed so you know the order of how it would go back on. There are many different wheels in many configurations, so there's no universal configuration of the hub, contact rings, etc. If you're putting on a factory wheel after you remove yours and don't have instructions, let us know if you need help with that.