Hi Fred, welcome to the Forums
If I was doing a 6 to 8 swap these are the things to check out:
-Suspension and brakes
- Due to the weight differences in various engines and components you need to work with this. On such an old vehicle, changing the coil springs is a definite must. (and shocks too!) Those 6's had the 4 lug wheel pattern. You should set it up for the 5 lug like all V8 classic Mustangs. You can use the spindles and brakes from a 69-73' (I think) to upgrade from the smaller weaker spindles and crappy front drum brakes. Also I would get new leaf springs for small block V8 mustang.
- Rear end and axle
- You can run an 8 inch rear end, but I would put a 9 inch. Beef it up and enjoy its strength. The 9 inch rear end's are bulletproof! Get the 5lug axles
A new radiator is also a good idea, especially the aluminum ones, they are performers.
You will also want to run dual exhaust system so your engine can breathe, and headers paired with kickass mufflers would help this alot.
There have been many articles in several Mustang magazine on doing 6 to 8 swaps over the years. You should check them out. Mustang Monthly is a very good one.
Good luck