And now for my favorite part of owning a mustang, customizing it! Beleive it or not that GT rumbling by you that sounds like a beast on wheels may actually get better gas mileage than your V6 does. It's kinda fun how some of these modifications go.
Exhaust
The exhaust system is a great way to get better mpg. From a simple muffler swap, to a full on high flow dual exhaust kit, you can net anywhere from 1-2 mpg. Most muffler companies advertise how much power you gain, but on the vehicles I've done an exhaust mod to I've noticed about a 5% gain in mpg. Don't forget about the headers! While there is the big debate about long tubes vs short tubes, either way you go as long as you don't "Enjoy" your new found power too much you'll still find a 2-3% gain in mileage.
Intake
Now in life you have to be just as concerned about what goes into the body as what comes out, and while exhaust can help your mpg's a fair amount, your intake can really get you going well. Adding a cold air intake, a ram air, or any other induction system (No sorry a turbo/supercharger doesn't count though we can all dream of a supercharger that improves our mileage) helps the engine breath better and thus gets more out of it. I've seen companies claim an upwards of 10% increase in MPG for a Cold Air Intake system, but realistically that rarely holds true. Personally with the mods I have (See forum signature) I get about 4 mpg better than stock ratings and I'm a "spirited" driver.
Electronic Modification
I've don't claim to have experience with these things, but the theory behind them is that by taking less electric or running a system that is more efficient you free up more energy to be used to turn into engine power instead of electronic power. You free this up by adding things like Underdrive Pulleys, Ignition Coils, and Spark Plugs. While I can prattle on for hours on things you can add, I'm just listing off those three because they can be easily found at Americanmuscle.com or Auto Zone.
Tuners
I r lazy that why I gots computers to do work 4 me. All modern cars have computers in them, they have been programmed to work around exactly what you have in your car stock. Well the makers of our wonderful mustangs tend to go conservative when it comes to dealing with our computers, but we wouldn't all be driving mustangs if we all where big on the "Slow" thing.

So by getting a Flash Tuner from a company like SCT, you can reprogram your computer to be faster, more fuel effecient, blah bah. It's just like any other computer you can make it do just about anything but sprout wings and fly if you try hard enough. SCT's new EcoTuner advertises a 10% gain on stock engines, so you can estimate 15-20% overall with modifications.
Fuel Catalyst
For those of you venturing to the extreme side of watching your MPG's, reviews have sided that the APSI company and their Fuel Catalyst product can net you an extra 1-2 mpg. Never tried it, I don't like tampering with my gas lines, but if your more confident than I, this is their website
Fitch Fuel Catalyst - Home