I have the 2011 V6 w/ Shaker500. I replaced my HU with a Pioneer, swapped my fronts for 6.5'' components, and added a 10'' sub in a sealed box. I unplugged the 8'' door woofers and am still using the rear speakers. Im using a 4ch amp for the front components and the rear stock speakers (I just have the gains set accordingly for the rear) and a mono block for the 10' subwoofer.
I ran new 16 gauge speaker wire for the front comps and for the rear speakers too. Getting the wire through the doors is a PITA. I used the AXXESS FRST wiring harness for my new pioneer HU and it retains full steering wheel control and full sync capabilities as well. I also used the Metra 99-5826ch dash adaptor.
With the door subs in it had too much bass up front. The bass from the door woofers was too loud and "boomy". Once I unplugged them and set the monoblock up, it was night and day in the quality of the bass. It was louder, deeper, and cleaner. Plus the doors dont rattle as much. I ended up not using sync at all now. I chose to just unplug the RCA cables from the audio in on the back of the HU. My new HU did everything sync could do, minus voice commands.
Goodluck on your install.
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2011 Kona Blue MT82 V6 Mustang Pony Package 3:31 Gear Ratio, Interior Upgrade Pkg, Security & Shaker500/Sync
Mods (in order of installed): AM Bama SCT SF3 Tuner w/ 87 Hybrid Tune, Airaid CAI, Hurst Billet Plus 2 Short Throw Shifter, Lethal O/R H Pipe w/ Stock Exhaust, Blacked-Out Tints on Rear Windows, Full Ceramic Tint on Front Windows, Metra Touchscreen Dash Adaptor, Single DIN Head Unit, 6.5'' Component Speakers Fronts, Stock Rear Speakers, 10'' Sealed Subwoofer, 4ch. and 1ch Amplifier. LED licence plate lights, LED interior dome lights, FRPP/Dynamic shocks and struts, SR Performance lowering springs, GT500 Strut Mounts, BMR Adjustable Panhard Bar, BMR LCA's, BMR Relocation Brackets. Rear Seat Delete.