I guess so. I've just had a look on Steeda's site at the new Wipple blower which now comes with the adaptive calibration. It does say;
"NOTE: 2005 and 2006 cars need to upgrade to the 2007 processor to use this system. Feel free to call for details."
I guess it comes in very pricey and the benefits don't outweigh the cost over a canned tune for most people. Shame, would have been great. Especially over here in the UK where there are hardly any shops familiar with the Mustang, so it's hard to get a custom tune.