Let me put this another way. If your engine was already running, and you put on some new heads, would you have to 'drain out' your old lifters in order to use them? Of course not.
Most Fords don't even have an actual adjustment on their pedestal style rockers. You have to make sure everything matches and fits, including the correct pushrod length. You bolt it up, and you're done. Not to say that you shouldn't check clearances and all that! The actual amount a hydraulic lifter should be compressed is something like .14" or so. They should not be mushy or soft, else they would never stand up to 110+ lbs of seat pressure closed, much less open, which is considerably higher. There's no slop.
The old tradition of soaking them, and using an old pushrod in some kind of handle to press the plunger and get them full of oil is largely irrelevant. I've never seen that cause problems myself. But they WILL fill with oil when you pressurize the oiling system either by priming your new engine's oil pump, or the first time you turn it over and it actually manages to start. So basically, it seems like a lot of wasted effort with your hands in motor oil, making a big mess, pumping on those slippery devils till your arms want to fall off.
Even if you turn over the engine without first pressurizing the oil system, it would still have to get the air out of the lifters before they could deliver full lift to the valves anyway, so I'd imagine it'd have a hard time starting until you've got oil in them. The only difference is that you'd be filling them by cranking your starter a long time, instead of priming your pump through other means.
In my humble opinion, it is far better to prime the engine and ensure that air is out of the oil galleys before that critical first start, and verifying that you can deliver good oil pressure. That way you can determine if there is a problem long before the engine fires. Doing so would inevitably fill all the lifters. I have never seen a lifter explode from 40-60 lbs of oil pressure, or malfunction because the oil pump was being run by a drill. Nor have I seen them suddenly go hog wild and shove the pushrods too far out, when the pushrod length and valvetrain geometry was correct, even after normal pressure was delivered.
Checking their pre-lash - even after priming the oil system, or after your first start - would not automatically mean that they can't be adjusted correctly simply because the lifters aren't full of air anymore.
All this, to get back to the original issue, which is: What make of lifters are you running, and when you say "hydraulic lock-up" do you mean that they are collapsed, or that they are full and doing more or less what they're supposed to do - except that you seem to be having a problem, Herbie?